this post was submitted on 25 Apr 2025
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[–] [email protected] 2 points 1 day ago* (last edited 1 day ago) (1 children)

I take Tylenol whenever I have a headache, but otherwise none. I was on and off a few for a while, but better exercise fixed my various issues better than any pills did.

I'll probably pick them back up when exercise isn't enough, but it's hard to say how many I'll be at by then. Maybe 10? I trust the science :P

[–] [email protected] -1 points 1 day ago (3 children)

Tylenol is nearly useless, straight up bad for you, and plain dangerous. If it came out today it wouldn't be sold over the counter. It's seriously one of the worst NSAIDS, there's literally no reason to be using it over Ibuprofen.

[–] [email protected] 3 points 1 day ago* (last edited 1 day ago) (1 children)

Tylenol (acetaminophen) is not an NSAID.

Ibuprofen is.

Ibuprofen particularly can mess up kidneys and stomach lining with chronic use especially. Meanwhile Tylenol tends to be a bit harder on the liver but is otherwise generally considered safer. This based on my hospital stay as a patient and the doctors veering me away from ibuprofen and toward tylenol, and my wife who is an RN.

I very much avoid both to the best of my ability but ibuprofen in particular (even though for me it's WAY more effective), and the only time I've really used either with any temporary regularity was with kidney stone, pneumonia, sepsis (all three at same time, mind you), and omicron covid I think it was. Tylenol is generally considered to be safer than Ibuprofen, unless you have preexisting liver issues.

[–] [email protected] 1 points 1 day ago* (last edited 1 day ago) (1 children)

You believe what you want. It doesn't change the fact that literally tens of thousands of people end up in the hospital each year because of acetaminophen and that it is the leading cause of liver failure in multiple countries. Unless you have specific kidney problems, or are one of the minority of people (<20%) with asthma who react poorly to it.

Ibuprofen carries risk with continued use. Acetaminophen caries risks with a single over dose, which is only a couple of pills over the daily recommended maximum dosage.

[–] [email protected] 2 points 23 hours ago (1 children)

My dude, what are you actually talking about? Call me a skeptic but I must take with a massive grain of salt what you say when you confuse Tylenol as being an NSAID — something that is very easily looked up; so I can't even tell if you're confusing studies conducted on Ibuprofen versus Tylenol.

The studies you mention elsewhere:

  • Yes, if you take FOUR GRAMS within a 24 hour period, that can cause damage. People are dumb and don't read labels and take in excess.

  • If you take the recommended dosage of 325mg even every 4 hours as opposed to 6, you're still under 2 grams in a 24-hour period.

  • Yes, Tylenol is less effective than Ibuprofen for things like headaches and inflammatory pains because — again — it is NOT a Non-steroidal anti-inflammatory drug (NSAID).

  • Don't be stupid: Don't take Tylenol with Alcohol, use it acutely, and follow the instructions and you'll be fine so long as you discuss with your doctor. Not rocket science.

Obviously the dose makes the poison. You can literally poison yourself by drinking water in excess, too.

[–] [email protected] 1 points 22 hours ago* (last edited 22 hours ago) (1 children)

FFS, just read my other comment which linked to sources.

https://sh.itjust.works/comment/18204895

[–] [email protected] 1 points 22 hours ago* (last edited 22 hours ago) (1 children)

You need to start reading things more closely. Are you stoned right now or something? If you actually read what I wrote, you would recognize that I had already read those sources. If you read more closely, you would probably know that Tylenol is also not an NSAID.

[–] [email protected] -1 points 22 hours ago* (last edited 22 hours ago) (1 children)

Fine you're right I should have been very specific and said over the counter pain killers.

Now address the actual point.

[–] [email protected] 1 points 21 hours ago

Already did. This discussion is useless. Bye.

[–] [email protected] 2 points 1 day ago

NSAIDs worsen my asthma so I have no other choice besides staying in pain 🥲

[–] [email protected] 1 points 1 day ago (2 children)

Strong claim is gonna require evidence, since literally every paper I see on the front page of Google search says the opposite. For example, https://pubmed.ncbi.nlm.nih.gov/20236342/, "A randomized, placebo-controlled trial of acetaminophen for treatment of migraine headache", found "Significantly (P = .001) more patients treated with acetaminophen 1000 mg reported mild to no pain after 2 hours (52.0%) compared with those treated with placebo (32.0%)"

[–] [email protected] 2 points 18 hours ago (1 children)

What the actual fuck? I feel like that can't be migraine. Tylenol makes mine worse (nausea), and has never worked for any other pain. Just makes me feel vaguely poisoned.

I don't actually take OTC painkillers much at all, maybe once a year. But the sumatriptan injection for migraine is amazing for mine - no drugged feeling, no up no down, just unwinds the headache. That stuff has worked as rescue medicine for my (once a month or fewer) migraines for 25 years now.

[–] [email protected] 1 points 17 hours ago

Super glad you have something that works for you. Tylenol on it's own doesn't cure my migraines either (I only use it for regular headaches), but Tylenol + Advil cures my migraines (whereas each on their own don't do squat)

[–] [email protected] 4 points 1 day ago* (last edited 1 day ago)

https://www.cochrane.org/news/featured-review-oral-paracetamol-treatment-acute-episodic-tension-type-headache-adults

The International Headache Society recommends the outcome of being pain-free two hours after taking a medicine as a standard measurement. The outcome of being pain-free or having only mild pain at two hours was reported by 59 in 100 people taking paracetamol 1000 mg, and in 49 out of 100 people taking placebo. This means that only 10 in 100 or 10% of people benefited because of paracetamol 1000 mg.

Meanwhile the recommended dosage is really really close to the dangerous dosage. Tens of thousands of people a year in the US alone suffer from liver damage or failure because of it.

https://www.drugwatch.com/drugs/tylenol/

Findings from one 2022 clinical research trial suggested that regular daily intake of 4 g acetaminophen increased systolic blood pressure in individuals with hypertension by about 5 mm Hg compared with a placebo. The study concluded that this increase in cardiovascular risk calls into question the safety of regular acetaminophen use in similar situations.

It is the leading cause of acute liver failure in the U.S., and the drug in some cases has led to fatalities. The active ingredient in Tylenol, acetaminophen, accounts for more than 100,000 calls to poison centers, roughly 60,000 emergency-room visits and hundreds of deaths each year in the U.S. In England, it is the leading cause of liver failure requiring transplants.

This is all pretty well known facts by now.