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A. Consume less cartel produced drugs.
B. Stop giving the cartels guns
Honestly, we shouldn't consume drugs at all, but to each their one I always say.
However, I completely agree that the ATF should change their policy and prohibit ALL gun sales without a US identification and simple background check at least.
You're gonna have a hard time defining "drug" in a way that all people agree with.
Presumably you don't mean prescription medications, though of course many of them are abused. Does caffeine count? Coffee is linked to many measurable health benefits. What about alcohol? No health benefit and a clear risk of abuse, but there's also thousands of years of social history, and I think plenty of people would say that, at least sometimes, the benefits of a great night out with friends or meeting new people and developing new relationships is more than worth the cost.
Then you have things like hallucinogens, which generally have only minor health concerns and were mostly criminalized for political reasons. Marijuana is literally a plant, and while the health profile is mixed, at least for some people, it's without a doubt a net positive. In comparison, and especially relevant to Mexico, there's heroin, which is incredibly addictive and dangerous while also funneling tons of money into the cartels.
I'm not trying to be pedantic here, but more to make the case that any kind of policy or position on "drugs" as a whole is way too widely scoped. There are too many different substances with drastically different social and medical costs and benefits. Probably no one should ever consume heroin or meth. People with a risk of schizophrenia should absolutely not touch LSD, but people with PTSD may genuinely benefit from MDMA. Alcoholics should never touch alcohol, but your average person having a few drinks on a Friday night out with some friends probably isn't making a bad decision.
The relevant ones are the ones cartels make money trafficking or producing: opiates, cocaine and meth.