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Yes you can change personality drastically.
Generally speaking, anything described as a “spiritual practice” will tend to alter people’s personality to the degree they put effort into it.
It’s not normal for personality to change much. People’s personality changes under relatively rare conditions: trauma, enlightenment, extreme conditioning.
Another commenter mentioned psychedelic drugs and those are definitely catalysts for personality change.
The things that have changed my personality the most are:
By “personality” here I’m talking about emotional patterns, which become the foundation for all sorts of beliefs, tastes, tendencies, social roles.
By emotional patterns I mean the overall averages of joy, sadness, fear, openness, guilt, etc, both over time and also in their typical daily cycles.