Absolutely, yes, I've had it disabled since the first W10 feature update. It gets harder with every new release, but it is doable.
You need to manually disable these services with Regedit
-Update Orchestrator (UsoSvc)
-Windows Update Medic Service (WaaSMedicSvc)
-Windows Update (wuauserv)
-Microsoft Edge Update Service (edgeupdate + edgeupdatem)
-Microsoft Edge Elevation Service (MicrosoftEdgeElevationService)
Then you need to go into Task Scheduler and disable all the tasks under the services listed above. I'd also suggest not using Edge, as it will now aggressively repair Windows Update, even with all this stuff disabled.
Outlook 2010 is better than this new office 365 shit too.