bjoern_tantau

joined 1 year ago
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cfs
[–] [email protected] 17 points 1 day ago* (last edited 1 day ago) (11 children)

How thin do you want to stretch it? Dragonball is based on the old Chinese myth of Journey to the West. Neon Genesis Evangelion is based on Christian myths.

[–] [email protected] 3 points 1 day ago

If I wasn't using so many other Nextcloud apps besides the file storage I would switch.

[–] [email protected] 31 points 2 days ago

Tons of books. Basically anything made before the 1900s.

[–] [email protected] 5 points 2 days ago

My cousin programmed a simple labyrinth game on my C64 by randomly placing symbols on the screen and you had to get the cursor from the upper left corner to the lower right without bumping into a symbol.

I was so impressed.

[–] [email protected] 2 points 3 days ago* (last edited 3 days ago)

Definitely 1. The second one wasn't bad. I mean, nothing beats a katana fight in trailer a flying through a tornado. But something about that game was always missing for me. I couldn't lay my finger on it (apart from Cate's actress changing). And I hate the endlessly respawning enemies.

[–] [email protected] 3 points 3 days ago

Either way I think you need a cold shower!

[–] [email protected] 20 points 4 days ago (4 children)

No One Lives Forever

To this day I have no idea why I bought it. And I bought it close to its release date. I would only do that if I had been absolutely obsessed for months with previews and stuff. But I remember none of that.

And still it ended up becoming one of my all time favourites.

[–] [email protected] 7 points 4 days ago

Yeah, the trouble was that this show was explicitly produced for Amazon. Maybe the writing was already on the wall and that is why they didn't put in any effort.

[–] [email protected] 15 points 4 days ago (3 children)

That shit was even bad if you had it ad-free through Prime. Watched a show there and it would have a half second black screen at the place where an ad would be. Sometimes in the middle of dialogue.

[–] [email protected] 4 points 5 days ago

Jaina Solo aka Sword of the Jedi

insert explanation that I'm too tired for

[–] [email protected] 4 points 5 days ago (1 children)

And people say Linux lets the user shoot himself.

[–] [email protected] 25 points 5 days ago* (last edited 5 days ago) (2 children)

I don't think period trackers can be used for that because schedules and such are supposed to alert you to something. But with period trackers you tell them when something happened. Specifically when the first blood and the last blood appeared. I don't think any of them give you a message of "expect to feel awful today".

But maybe they can be used to track natural occuring cycles like when a fast growing plant is ready for harvest maybe.

Edit: I often use Did I take my meds as a flexible scheduler.

 

Dr Becky, PBS Space Time and Angela Collier all release on the same days. Giving me one big day filled with quality astro physics. But leaving all other days devoid of good content. It would be nicer if they staggered a little.

Posting here for a lack of !verymildlyinconvenient.

33
submitted 5 months ago* (last edited 5 months ago) by [email protected] to c/[email protected]
 

With every version of Android it seems to be harder and harder to get real time notifications anywhere near real time.

Twitch notifications, Signal, WhatsApp, I often get these ten to thirty minutes too late.

I've excluded them from battery optimisation but that doesn't seem to do anything. And I can't find anything else.

I don't care about battery usage. I'm always near a charger.

Android 13 on a Fairphone 3.

Edit: I've disabled DOZE according to https://stackoverflow.com/questions/40204605/android-completely-disabling-deviceidle-doze-in-android-m Hopefully that helps.

319
Old News (swg-empire.de)
 
 

cross-posted from: https://swg-empire.de/post/705254

Camera filter app for children

Does anyone know of a free privacy friendly camera app with funny filters and/or vignettes I can give my children to play around with?

Preferably open source but I've already looked through F-Droid and couldn't find anything.

42
submitted 8 months ago* (last edited 8 months ago) by [email protected] to c/[email protected]
 

I want to migrate my Nextcloud instance from MariaDB over to PostgreSQL. I already have a PostgreSQL service running for Lemmy. And I'm pretty starved for RAM.

Would it be better to just have one PostgreSQL service running that serves both Nextcloud and Lemmy? Or should every service have its own PostgreSQL instance?

I'm pretty new to PostgreSQL. But in my mind I would tend towards one service to serve them all and let it figure out by itself how to split resources between everything. Especially when I think that in the long run I will probably migrate more services over to PostgreSQL (and upgrade the RAM).

But maybe I am overlooking something.

Edit: Thanks guys, I've settled for a single instance for now. And after a little tuning everything seems to be running better than ever, with room to spare.

 

cross-posted from: https://kbin.social/m/mecfs/t/844768

Immunological Patient Stratification in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Rohrhofer et al 2024 (full text)

Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease characterized by profound fatigue, post-exertional malaise (PEM), and neurocognitive dysfunction. Immune dysregulation and gastrointestinal symptoms are commonly observed in ME/CFS patients. Despite affecting approximately 0.89% of the general population, the underlying pathophysiological mechanisms remain poorly understood. This study aimed to elucidate the relationship between immunological characteristics and intestinal barrier function in ME/CFS patients. ME/CFS patients were stratified into two groups based on their immune competence. After documentation of detailed medical records, serum and plasma samples were collected for the assessment of inflammatory immune mediators and biomarkers for intestinal barrier integrity by ELISA. We found reduced complement protein C4a levels in immunodeficient ME/CFS patients suggesting a subgroup-specific innate immune dysregulation. ME/CFS patients without immunodeficiencies exhibit a mucosal barrier leakage, as indicated by elevated levels of Lipopolysaccharide-binding protein (LBP). Stratifying ME/CFS patients based on immune competence enabled the distinction of two subgroups with different pathophysiological patterns. The study highlights the importance of emphasizing precise patient stratification in ME/CFS, particularly in the context of defining suitable treatment strategies. Given the substantial health and socioeconomic burden associated with ME/CFS, urgent attention and research efforts are needed to define causative treatment approaches.

1
submitted 9 months ago* (last edited 9 months ago) by [email protected] to c/[email protected]
 

A while ago I moved in with my parents to relieve my wife from having to juggle two kids, the household, her elderly parents, her work and me. And my parents have this fancy digital thermostat I can control from my smartphone.

At the start I had it set to 17° C. But by now I have it at 15° to feel comfortable. Granted, I lay under a blanket most of the time. But higher temperatures also feel bad on exposed parts of my body.

Kind of feels like my body is slowly shutting down. It's a little bit unsettling. No idea what I will do in the summer. We only have a radiator and no AC.

 

cross-posted from: https://kbin.social/m/mecfs/t/827670

ME Research UK and the ME Association announce funding for a study that aims to create a diagnostic test for ME/CFS

In 2019, Professor Ron Davis from America reported that researchers had developed a nanoelectronics test that could detect an impedance in white blood cells taken from people with ME/CFS1.

They felt their findings could represent a diagnostic marker, but since then there hasn’t been any further research in this area. ME Research UK and the ME Association have jointly funded a new 12-month study that will build upon these initial findings.

The research grant has been awarded to Professor Robert Dorey, Dr Fatima Labeed and Professor Michael Hughes from the Centre for Biomedical Engineering at the University of Surrey, and Dr Eliana Lacerda and Caroline Kingdon from the London School of Hygiene and Tropical Medicine and the UK ME/CFS Biobank.

The UK researchers have already used a more robust approach to identify statistically significant differences between the electrical properties in blood from people with ME/CFS compared to healthy and multiple sclerosis (MS) controls (using samples from the UK ME/CFS Biobank).

Their preliminary work suggests that the 2019 results from America are repeatable and can be explored in more detail. Furthermore, that they have the potential to be used as a routine diagnostic test.

(More in link)

 

I'm too brain fogged to really understand it, but it seems like the ME/CFS research is also having good results.

 

Roughly translated, the immune system keeps fighting. They found the proteins persisting in the blood of Long Covid patients. They lead to blood clots and other stuff. Most importantly this can be tested for.

Hopefully this is applicable to CFS/ME as well.

 

cross-posted from: https://swg-empire.de/post/446692

New insights from the German exercise physiologist on how to pace with ME/CFS (especially in order to avoid viral reactivation through overexertion)

Interesting thread from Reddit.

TLDR for the link: This professor suggests that, as a pacing regimen, you never exert any muscles for longer than 30 seconds at any one time. After any such exertion, you need to have a break of 30 seconds of rest. Otherwise hypoxic damage of the muscles is bound to occur which leads to PEM the next day or day after. When you avoid PEM for a sufficiently long period of time, and exert yourself only in a safe manner, then, according to his experience, you can recover (go into remission).

TLDR for this post: More findings and recommendations in connection with this method. Plus explaining how overexertion leads to the flu feeling that some experience, through viral reactivation. I have highlighted the relevant section below for you to find in bold, if you want to read about that part in more detail.

Only recently I found him speaking in German podcast on ME/CFS for which he was interviewed on the subject of pacing with ME/CFS specifically. (For fellow German speakers, here is the link)

You will make more sense of the below points if you are familiar with his approach of the 30/30 seconds rule already, so you might want to take the time to read up on the original post linked above, in case it's all new for you.

Ok, so here are some more interesting insights from Dr. Simon that I only happened upon recently in the above mentioned podcast interview, specifically for ME/CFS:

(All these points reflect what he says in the podcast, but it's not a comprehensive list for the whole interview, because I only jotted down what was either new for me or else reiterated what I thought was worth reiterating again. If I have left something out that seems important, please, German speaking friends, post it below, so that we don't miss anything for the friends who are not German speakers but would also like to know everything that was being said and explained.)

Here goes:

  • It typically is easier to go into remission and regain impressive function with his 30/30 seconds pacing regimen if you have suffered with ME/CFS for a long time already and have a stable baseline than if you are newly and severely affected by the Long Covid version of ME/CFS that's all fresh. An explanation for this is, that typically new Long Covid patients still have very active auto-antibodies that cause more disruption to the system than it is the case in longtime ME/CFS sufferers. The ME/CFS sufferers' antibodies willl have calmed down over the years already.

  • He tells the story of an ME/CFS patient of his who went into full remission with this 30/30 pacing strategy after having been very ill with ME/CFS for many years. She started with a simple 30 seconds standing up exercise only and slowly slowly slowly (this can not be emphasised enough) worked her way up to now being able to go for runs in 14 km/h and 7 km/h intervals again. 7 km/h is a light jog, according to him. So I would guess that 14 km/h is decent running. (Note: 14 km/h are 8.7 miles per hour and this translates to 6 minutes 54 seconds per 1 mile.)

  • He considers mild to moderate ME/CFS sufferers to generally still be in comparably quite good physical condition as they typically can still do impressive things if need be (of course they will crash if they overexert, but just speaking of strength, they still have an impressive capacity and function considering how ill they are and feel). It is these patients for whom his method can effectively yield very good results, if they learn how to not overexert themselves again. Note: especially dangerous on good days where people tend to overexert themselves. This is detrimental. It doesn't work. According to him, no one ever recovers by exerting themselves over capacity on good days.

  • ME/CFS patients' lives are so difficult because they are stuck in a vicious circle of overexertion all the time. If these patients got the chance to truly pace, then they would not be so sick and they could recover. But the daily overexertion of just basic hygiene and household chores keeps them in a loop that keeps them low functioning. It's a vicious circle.

  • Mental and emotional exertion have the same detrimental effect as physical overexertion. They have to be avoided if one wants to regain their health. Emotional exertion can also happen if exciting positive things happen, like a visit from a friend you have been looking forward to see. Patients will need to find a way to emotionally pace. This is important.

  • Micro circulation issues: The whole problem is that the muscles and tissues don't get sufficient oxygen from the blood (which is perfectly oxygenated) anymore. This is a problem of micro circulation. It happens because some of the important cells for this to work are destroyed by auto-antibodies after an infection. But, and this is the important bit, they can come back. New cells can form again. And the vascular system must learn how to regulate blood flow again. This happens in the 30 seconds break (the "awarding break" where we sense and assess how we feel and where we rest and give the system a chance to learn). Such learning will take weeks, months and sometimes years to come to full fruition. But the body can do it if you give him the breaks and opportunity to adjust very very slowly.

  • Activities where you need to use your hands over your head (like shampooing your own hair) will be extremely exhausting, because the blood needs to flow against gravity even higher up and the body of ME/CFS patients can't tolerate it. The 30 seconds rule doesn't work here. It needs to be less. Like 5 or 10 seconds. Then rest before you continue.

  • When going for a slow and careful walk in accordance with the 30/30 rule, some ME/CFS patients need to sit down for the 30 seconds break while others can stand still or walk very very slowly. For the more severely affected folks, when sitting down they will need to raise their legs and rest their head on their knees to get the beneficial effect from the 30 seconds break. So not everyone will be able to go for walks right away, as a training, even if they can technically walk for 5 minutes. If they need their rests to include sitting or lying down, when there is no opportunity along the way to do so, then walks are not possible yet. Stick to simple standing up training at home. Sit down immediately when you feel unwell. If you can't yet stand up and tolerate it, start with sitting up and lying down again. If you can't tolerate sitting up yet, start your "training" by only raising your arm for a few seconds and then have a break and see how you tolerate it.

  • As far as breaks are concerned: Switching between physical exertion and cognitive exertion unfortunately doesn't work as a break. It's not a real break, but we need real breaks. "Awarding breaks" as explained in the original post.

- Intense overexertion can lead to viral reactivation. (He says that sports physiology has shown this already 10 years ago)

Overexertion apparently "lures" back viruses from the tissue into the blood. But not only the virus itself, but also lymphocytes (which react to the virus)!

He says that this is what immediately leads to the patient feeling ill and feeling as if they had the flu or were about to getting the flu. It's the overexertion that facilitates this. And it's "definitely not good!" (quote as emphasized by Professor Simon).

Therefore patients who want to recover their health need to avoid such exertion intensity that leads to these immediate flu feelings. It's all about the intensity. (He emphasizes that word.) He says that unfortunately it can also be emotional or cognitive intensity that does this.

Once the viruses are reactivated then it can take 4 to 8 weeks (without any overexertion or too much physical or emotional intensity) before the situation calms down again.

This is the time when it can be "dangerous" to fully retreat to your bed and lie down for many weeks, as deconditioning happens on top of it and it makes everthing worse.

In case this reactivated virus thing happens to you, you should try extremely carefully to stay active in some way, but be extremely careful to not overexert yourself and to dial down on any mental (cognitive) or emotional intensity. (That's why for some patients psychotherapy is extremely helpful when they learn to calm themselves before intense emotions even happen).

He says that these flu symptoms don't always mean a full viral reactivation in every case. But when these flu feelings and symptoms happen, it points to too much previous exertion intensity. And that that is the intensity that you will need to avoid in future in order to recover.

His whole approach says to not be afraid of exertion in general, just 100 % avoid overexertion.

Bear in mind that muscle use of less than 30 seconds generally is safe when it is followed up by a 30 seconds break. And if you are at a stage where you have a steady baseline already that is bigger than these 30 seconds. If you are severe and bed bound than 30 seconds will be too much for you at this stage. You need to start smaller.

And also with taking stairs, the 30 seconds rule might not apply for you yet, even if it works well in other areas. It's more complicated due to the complex nature of the thigh muscle. You need to be even more careful. Take 3 steps, then rest 30 seconds. Then take the next 3 steps. It will take you longer to get up the stairs, but it generally will not exhaust and destroy you. (Of course this doesn't apply yet to patients who are still bedbound.)

If as an ME/CFS patient you do happen to overexert, make sure to rest the day after and day after that. Big crashes for ME/CFS patients, in his experience, happen not after one simple overexertion on one day, but after overexertion and then more overexertion on the next day and the day after as well.

EDIT: Another important message I just remembered, is: that generally, once the vascular function and microcirculation is restored with this pacing strategy, the recovered person will have their full capacity again. That means that a former professional athlete who is bedbound post Covid will not have to start from zero (like an untrained person) after recovering. This shows that it's not a matter of deconditioning. Once the circulation is restored, people can fully use their muscles again and walk 30 kilometres is necessary, without having to train up months to do it. The normal energy will be fully restored.

EDIT 2: Here is Prof. Simon speaking in English at a conference about this. It is a very technical talk to his colleagues, and unfortunately doesn't contain much info for patients on the 30/30 method. But in case you want to check him out nevertheless: from 46:32 onwards in this Vimeo link: https://vimeo.com/771944349 (thanks to u/Electrical-Fault301 for finding this and letting me know).

With that...

For me, my time on the sub ends here. Not because I am already fully recovered, but because the other day I read a seemingly random statement in a comment that said that people who get better from CFS don't keep hanging around on the CFS sub. I have been searching my soul and have now decided to take a leave from the sub and potentially even reddit as a whole, to see where it takes me. I want to go into full remission and I feel like hanging on to the sub and all the excitement (i.e. the intensity) that comes with posting on here (with my controversial views on the health benefits of calming your system with re-education (retraining) of the nervous system) is not allowing me to fully move on and fully pace the way I want to.

I feel my views on nervous system re-education are totally in line with what Prof. Simon is suggesting with his findings, that emotional pacing is key too, that we need to dial down intensity ourselves, and that the body can learn to regulate itself again, even when you are severely dysfunctional and your vascular system doing its own thing and causing you an insanely high heart rate. But arguing about my views in comments with users who feel like re-educating your nervous system or doing trauma therapy couldn't possibly have any health benefits for "real" or "true" CFS patients, is not going to bring me the calm I need for where I want to be.

I wish everyone on the sub, no matter if friend or foe (of my views and comments), health and happiness ❤️

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