Snopes says this
What's True Tobacco enemas were a real and at one time popular medical practice thought to have been able to revive people who had drowned or were otherwise catastrophically ill. What's False However, the phrase "blow smoke up your ass" appears to have its origins more recently, in the 1960s, and there is no evidence linking it to the long-ago practice of tobacco enemas.
That’s ridiculous, he’s obviously Jesus Christ.