Ranvier

Wow, what a dumb design. It actually looks less like it's braking with the brake lights on.

It's also got the whole brake light and turn signal are the same light thing I hate too. Just keep them separate lights with a yellow light for the turn signal.

If it was getting into the blood it should be doing about the same thing as pseudophedrine since they share a mechanism. You certainly shouldn't take either if they make you feel terrible though, and probably talk to your doctor about it. The way both medications are supposed to work is vasoconstriction, which could be a big problem if there is already high blood pressure for instance.

There's a lot of evidence out there showing no difference between phenylephrine and placebo, probably because of low bio-availability at low doses. One study below, there are many others:

https://www.annallergy.org/article/S1081-1206(10)60240-2/fulltext

That's a good point and goes for pretty much any "insomnia" medication. None have good evidence for helping in the long term. The only intervention that has good evidence for chronic insomnia isn't a medication, it's cognitive behavioral therapy for sleep. Unfortunately that can be difficult and expensive to access, there's not a ton of psychologists or counselors that do that.

Very true! Benadryl was primarily intended for use as an allergy medication, though it's common for meds to get repurposed like this if they have other effects. Histamine in your brain is important for maintaining wakefulness. Non-drowsy allergy medications avoid this by making sure they can't get past the blood brain barrier.

All those pm meds are just branding. Unless you're also in pain or have a fever and too lazy to take two pills or something, there's no real benefit. Just a glance at amazon shows the unit price of tylenol pm vs the same dose of generic benadryl (diphenhydramine) is 12x more! There's multiple meds like this in the over the counter section, always read what the actual active ingredients are, not just the branding. I'm particularly annoyed by all the combination products that wrap tylenol/acetaminophen in them, or an NSAID (ibuprofen, naproxen), as it could be easy to accidentally overdose those if you were also taking them separately or a very similar med.

No this is about phenylephrine, which is a vasoconstrictor. Allergy meds are a much different category, usually the pills are anti-histamines. The nasal sprays are usually a corticosteroid (there's different ones too though). Anti-histamines can certainly have side effects though, especially the ones that don't say non-drowsy, as anyone who's taken benadryl could tell you. I'm glad they pulled phenylephrine. I personally noticed it seemed to have no effect, and use pseudophedrine whenever I feel like I want a decongestant.

Pseudophedrine is clearly effective and still readily available, it's just behind the counter and you have to ask for it (can be used in manufacturing meth). Phenylephrine is the one being pulled here, it was primarily pushed so they could have a cold medicine that didn't have to be behind the counter. The picture here is slightly confusing because it is sudafed, which people generally associate with pseudophedrine, but in this case it's sudafed PE, which is phenylephrine (the one that doesn't work). Check the active ingredient on whatever one you're using.

Pro tip, ghostery add-on for Firefox. Works on both desktop and mobile. Automatically goes through the cookie pop up when you load a page, denying all, among other functions.

My understanding is the exchange itself wasn't really their downfall. Their downfall was was using the money deposited with them or invested into their company to gamble on risky trading with an affiliated investment firm. They kind of ran this firm, it was supposed to be separate but really wasn't. It sounds like at least $10 billion was moved from the exchange to this investment firm, who lost most of it. Didn't help that the main thing that firm was involved in was.... buying crypto of course. In an incestuous ouroboros of fraud.

But yeah I think you're right, even if they hadn't engaged in all that fraud, how does an exchange determine how much money in usd and different cryptocurrencies to keep on hand to safely cover all depositors with them when there is such dramatic volatility in all the different cryptocurrency values? Every crypto exchange is probably doomed to a massive dramatic collapse at some point or another just from a volatility standpoint alone. Not to mention the massive underlying issues with many cryptocurrencies like wasting energy, wasting resources, co2 generation. Hard to argue there's such a thing as a "legit" exchange.

Alright, we'll just rip the implants keeping patients seizure free out of their heads and tell everyone with Parkinson's sorry, brain implants have to be removed now, go back to being frozen. Saying we can't use a technology because someone might do something bad with it someday could apply to literally any technology.

Or are you proposing getting rid of legal frameworks and regulation of medications would improve them somehow? Just let big pharma go realky wild? Strengthen our regulatory frameworks by all means, stop regulatory capture and all that, but an unbridled free for all with big pharma allowed to do, sell, and say whatever it wants about its products sounds horrific. I think you're right to think the fda may have gotten a little too lenient with some approvals lately, but that's an argument for stengthening the regulations not getting rid of them.

But yeah Elon isn't allowed to sell this shit yet, and people have to elect to be involved in any trials. It's their choice. If he ever tries to sell it, he'll have to prove efficacy and safety. Without that regulatory framework he wouldn't need to do even that, could just immediately launch it and lie about the capabilities a la tesla auto pilot, duping and killing a bunch of people likely.

Yeah, what is this meme? Like I get Elon is a douche. But I mean where do people think deep brain simulation and things that help tons of people already come from? We even have implantable devices that can record seizures directly from the brain surface and generate electric impulses to disrupt them. Not to mention pacemakers, spinal cord stimulators, etc. All these things have quite a lot of regulatory hurdles before reaching market. Obviously want to make sure that framework stays strong so no dystopian nonsense down the line happens. Once we get to the level of consumer grade brainchips, then I'll start to worry.

I feel Sturgeon's pain. Was just in an old book shop that had every genre imaginable including even cookbooks and weird old junk books about the paranormal and casting spells, trashy romance stuff, old historical records, all sorts of random crap. I asked if there were any science fiction or fantasy books. Owner of store: no we don't stock that stuff, we only stock things of literary value.

Alright buddy, geeze. Yeah no sicence fiction or fantasy of any literary value was ever written I guess.

If this graph isn't just made up bs in the first place, one thought I recall from every major college campus I've been to is random religious preachers camped out every day telling everyone they're evil, subhuman, and going to hell. Guessing the atheists find that a little more annoying and worthy of shouting back at than some of the religiously inclined.