I personally would say: "interesting, Why's that?" And listen to what they have to say about it.
I ask myself the following: "does this person treat me well? Do they treat others well?" If yes is the answer to both questions, then I just move on. Who cares if they would vote a different way than you in an election they can't vote in anyway?
I hate to point it out to you, but you most likely are friends with a DeSantis supporter or two. People are very much willing to lie about or omit who they vote for in order to maintain social relationships, and if you could look into others personal thoughts, you'd probably be very surprised to find out who of your friends are.
When politics are cut out of the equation, you'll find you can be friends with DeSantis supporters, just as long as you're kept in the dark.